DNA Sequencing Library Preparation System: MGISP-100
The MGISP-100 is an automated laboratory workstation purpose-built for DNA sequencing library preparation, combining a fixed 8-channel pipetting head with integrated PCR, magnetic-bead purification, and temperature-control modules.
Manufacturer: MGI — Latvia
Overview
The MGISP-100 is an automated laboratory workstation purpose-built for DNA sequencing library preparation, combining a fixed 8-channel pipetting head with integrated PCR, magnetic-bead purification, and temperature-control modules. It automates roughly 90% of the library preparation workflow, processing 8 to 16 samples per run, with a standard throughput of 16 samples per run, while removing operators from repetitive manual steps. Built-in UV disinfection and HEPA filtration protect against cross-contamination throughout the run. The MGISP-100B configuration extends the platform to nucleic acid extraction and PCR setup, adding flexible throughput options for laboratories that need a broader workflow. As an open platform, the MGISP-100 supports customized script development, giving laboratories the flexibility to adapt the system to their own protocols.
Automated Workflow and Sample Throughput
The MGISP-100 automates approximately 90% of the sequencing library preparation workflow, reducing manual intervention and improving run-to-run reproducibility. It supports flexible sample processing of 8 to 16 samples per run, with a standard throughput of 16 samples per run, to match different laboratory demands.
Precision Liquid Handling
A fixed 8-channel pipetting head covers a volume range of 1 µL to 200 µL, with a coefficient of variation below 5% at 1 µL and below 1% at 200 µL. Pipetting accuracy is within ±10% at 1 µL and ±1% at 200 µL, and the robotic arm delivers positioning accuracy of ±0.1 mm for consistent, repeatable liquid transfers.
Integrated Temperature Control
An onboard PCR module operates across a temperature range of 4°C to 99°C, with an accuracy of ±0.3°C and a uniformity of ±0.2°C. A separate temperature control module spans 4°C to 90°C with ±1°C accuracy and uniformity, supporting reagent conditioning and enzymatic reaction steps within the same run.
Contamination Control
An ISO5 HEPA filtration system combined with a UV lamp delivering a radiation dose greater than 100,000 µW·s/cm² keeps the work area contamination-free. Together with an enclosed laminar flow environment, these features protect sensitive NGS library preparation reactions from cross-contamination.
Flexible Configurations and Open Platform
The MGISP-100 is available in multiple configurations, including a standard setup for library preparation and the MGISP-100B configuration for nucleic acid extraction and PCR setup. As an open platform, it supports customized script development so laboratories can adapt automated protocols to their own workflows.
Compact, Space-Saving Design
The system integrates its PCR, magnetic-bead purification, and temperature-control modules into a compact footprint of 725 mm × 780 mm × 777 mm and weighs approximately 130 kg. This space-saving design allows the MGISP-100 to fit onto a standard laboratory bench while consolidating multiple workflow steps into a single instrument.
Common Specifications
| Specification | MGISP-100 |
|---|---|
| Throughput | 16 samples/run (standard) |
| Pipetting Channels | Fixed 8-channel |
| Pipette Volume Range | 1 µL–200 µL |
| Pipetting CV | 1 µL < 5%; 200 µL < 1% |
| Pipetting Accuracy | 1 µL < ±10%; 200 µL < ±1% |
| PCR Temperature Range | 4 ℃–99 ℃ |
| PCR Temperature Accuracy | ±0.3 ℃ at 55 ℃ |
| PCR Temperature Uniformity | ±0.2 ℃ at 72 ℃ |
| Temperature Control Module Range | 4 ℃–90 ℃ |
| Robot Arm Positioning Accuracy | ±0.1 mm |
| HEPA System | ISO5 |
| UV Lamp Radiation Dose | >100,000 µW·s/cm² |
| Power | 100 V–240 V, 50/60 Hz, 1600 VA |
| Dimensions (W×D×H) | 725 mm × 780 mm × 777 mm |
| Net Weight | 130 kg |
| Operating Temperature | 19 ℃–25 ℃ |