DNBSEQ-G400
The DNBSEQ-G400 is a versatile benchtop sequencer for medium-to-large genomics projects. Supporting multiple read lengths and sequencing modes on MGI's DNBSEQ™ technology, it offers 55 Gb to 540 Gb per run with high accuracy, reduced duplicates, and low index hopping for applications from panels to whole genomes.
Manufacturer: MGI — Latvia
Overview
The DNBSEQ-G400 is a versatile benchtop sequencer designed for medium-to-large genomics projects. Supporting multiple read lengths and sequencing modes, it offers high throughput, accuracy, and flexibility for applications including cancer detection, transcriptomics, and whole-genome sequencing. Based on MGI's proprietary DNBSEQ™ technology, the DNBSEQ-G400 supports multi-sequencing modes with increased accuracy, decreased duplicates, and reduced index hopping.
Core DNBSEQ™ Sequencing Technology
DNBSEQ™ Technology combines DNA nanoball (DNB) rolling-circle amplification with patterned array loading and combinatorial probe-anchor synthesis (cPAS). Because each DNB is a clonal copy that does not amplify during sequencing, the chemistry avoids the error accumulation, index hopping, and duplication of bridge-amplification platforms, delivering high accuracy with low duplication rates. All MGI sequencers can run as standalone systems from sample to result without any network connection, keeping data fully secure.
Key Highlights
Data output of 55 Gb to 540 Gb per run with read lengths from SE50 to PE300.
Dual flow cell design supports two different sequencing modes simultaneously for flexible, mixed workloads.
High accuracy with decreased duplicate rates and reduced index hopping.
Suited to everyday laboratory workflows from targeted panels to whole-genome sequencing.
Applications
Whole-genome sequencing, exome and large panel sequencing, transcriptomic sequencing, cancer detection, methylation sequencing, and metagenomic profiling.
Data Security and Bioinformatics
Every MGI platform can operate as a standalone system from sample to result with no network connection, eliminating the risk of data breaches. On the analysis side, MGI's bioinformatics accelerators speed up secondary analysis: MegaBOLT reduces computational delays by up to 20 times over classical algorithms, and ZBOLT Pro, the ultra-high-performance version, achieves up to a 200 times increase in data analysis speed.
Specifications
| Specification | DNBSEQ-G400 |
|---|---|
| Data Output | 55 Gb to 540 Gb per run |
| Flow Cells per Run | 1 to 2 |
| Reads per Flow Cell | 300M to 1,800M |
| Read Length | SE50 to PE300 |
| Run Time | 14 h to 50 h |
| Q30 Quality | >85% |
| Flow Cells | Dual flow cell (two sequencing modes simultaneously) |
| Accuracy | Reduced duplicates and index hopping |
| Sequencing Technology | DNBSEQ™ (DNA nanoball, cPAS) |
| Typical Applications | WGS, exome and large panel, transcriptomics, methylation sequencing, metagenomics |